The molecular and functional effects of Type II metabotropic glutamate receptor (GRM2/3) gene deletion in the mouse brain. (360G-Wellcome-075405_Z_04_A)
The molecular and functional effects of Type II metabotropic glutamate receptor (GRM2/3) gene deletion in the mouse brain To characterise the molecular and functional profiles of GRM2/3 double knockout mice. This will be achieved by the following objectives: 1) Evaluating the expression of genes relevant to glutamate neurotransmission (e.g. glutamate transporters and NMDA receptors) in the brains of GRM2/3 double knockout mice; 2) Measuring long-term potentiation (LTP) and pre-synaptic activity in the hippocampus of experimental animals and controls; 3) Examining spatial working/reference memory, anxiety and locomotion in GRM2/3 double knockout mice and controls.
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Grant Details
| Amount Awarded | 11970 |
| Applicant Surname | Lyon |
| Approval Committee | Neurosciences And Mental Health |
| Award Date | 2006-01-23T00:00:00+00:00 |
| Financial Year | 2005/06 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 075405/Z/04/A |
| Lead Applicant | Ms Louisa Lyon |
| Partnership Value | 11970 |
| Planned Dates: End Date | 2008-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2005-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Dr Jeremy Taylor |