The role of electrical activity in the refinement of the Climbing Fiber-to- Purkinje Cell synapse. (360G-Wellcome-077527_Z_05_A)
The role of electrical activity in the refinement of the Climbing Fibre-to-Purkinje Cell synapse The main aim of this project is to understand the role of activity in refinement of neuronal connections during development. This question will be addressed at a defined synapse in the mammalian brain, the climbing fibre (CF) to Purkinje cell (PC) synapse of the cerebellum, where innervation by multiple CFs gives way to monoinnervation in the adult. I will use a combination of electrophysiological, molecular and imaging approaches, applied both in vitro and in vivo. Specifically, I will determine: The role of presynaptic activity in CF synapse elimination The role of postsynaptic activity in CF synapse elimination The short-term dynamics of CF elimination by visualising multiple CF's in vivo
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Grant Details
| Amount Awarded | 10224 |
| Applicant Surname | Rizzi |
| Approval Committee | Neurosciences And Mental Health |
| Award Date | 2006-10-12T00:00:00+00:00 |
| Financial Year | 2006/07 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 077527/Z/05/A |
| Lead Applicant | Mr Matteo Rizzi |
| Partnership Value | 10224 |
| Planned Dates: End Date | 2009-09-24T00:00:00+00:00 |
| Planned Dates: Start Date | 2006-09-25T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof David Attwell |