Regulation of a novel mirror-symmetric cell nervousdivision in the vertebrate nervous system. (360G-Wellcome-077538_Z_05_A)

Regulation of a novel mirror-symmetric cell division in the vertebrate nervous system To analyse the regulation of the zebrafish C-division (a novel mirror-symmetric division). Previous work suggests that the C-division is regulated by a timing mechanism, not its environment. Other work also suggests that this is the case, as this division is most often number sixteen after fertilisation (Kimmel et al, 1994). Therefore it is possible that cells are either able to measure developmental time or able to "count" the number of divisions. Cell intrinsic programmes of development that may rely on timing mechanisms have been proposed to operate in other neural progenitors both in invertebrates (Luer and Technau 1992, Grosskortenhaus et al 2005) and vertebrates (Qian et al 1998, 2000, Cayouette et al 2003, Shen et al 2006). This project will test the hypothesis that the C-division is regulated by a timing mechanism possibly related to cell cycle number.