Core Support for the Africa Centre for Health & Population Studies 2005-2007. (360G-Wellcome-077760_Z_05_B)

£83,000

The HIV pandemic continues to be the overwhelming health problem in southern Africa. In the Africa Centre Demographic Surveillance Area (ACDSA) HIV seroprevalence is 22% for all adults, and is over 50% in women 25-29 years. Half of all deaths are due to AIDS. During the coming five years, the Africa Centre will have as its major objectives: 1) Characterising the HIV epidemic and risk factors for infection; 2) Understanding how to better prevent and treat HIV and AIDS; and 3) Understanding the effects of the epidemic at the individual, household, and population level, including its effect on social structures. The Centre will use its Demographic Information System to track changes in the epidemiology of HIV; to determine behavioural and genetic risk factors for infection; and to develop models for projecting the future behaviour of the epidemic. The Centre will take part in international trials to test microbicides and vaccines for preventing HIV infection, and will design and propose a multi-component intervention for preventing HIV in adolescents. The Centre will support the ART rollout of the District Health Services, and will model ART delivery programs that use non-professional staff to deliver the majority of care. It will determine the effect of ART rollout on life-expectancy in the ACDSA, and assess how best to follow persons who are HIV-infected but don't yet need therapy; how to detect important clinical complications of therapy; and the importance of nutrition on response to therapy, and therapy on nutritional state. The Centre importantly will be able to determine factors associated with adherence to ART, and design interventions to improve adherence. The effect of the HIV epidemic on the functioning of households and individuals, including effects on employment and income, on development and education of children, and on health care utilisation, will be continuing themes of the Centre's research. The Centre will begin to study chronic non-infectious disease, with a focus on factors causing the metabolic syndrome and how to prevent it; and will start discussions to determine if a biobank should be established using ACDSA as a base. Lastly, the Centre will work to increase training opportunities for young South African scientists, especially those from previously disadvantaged backgrounds.

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Grant Details

Amount Awarded 83000
Applicant Surname Newell
Approval Committee Populations and Public Health Funding Committee
Award Date 2006-07-19T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Africa and Asia Programmes
Internal ID 077760/Z/05/B
Lead Applicant Prof Marie-Louise Newell
Partnership Value 83000
Planned Dates: End Date 2007-07-31T00:00:00+00:00
Planned Dates: Start Date 2006-08-01T00:00:00+00:00
Recipient Org: Country South Africa
Region International