The neuroanatomical basis of frontal lobe cognitive dysfunction in frontal lobe and idiopathic generalised epilepsies. (360G-Wellcome-079474_A_06_Z)

£244,430

Frontal lobe epilepsy is a common form of epilepsy that is often difficult to treat successfully with antiepileptic drugs. In some medically refractory cases, surgical treatment is possible, which carries risk of cognitive and behavioural deficit.Juvenile Myoclonic Epilepsy is associated with a particular personality, behavioural and neuropsychological profile that suggests involvement of frontal lobe dysfunction. The aim of this project is to investigate the functional anatomy of cognitive dysfunction in these two common forms of epilepsy. The objective is to better understand the functionalcorrelates of frontal lobe disorders, and to explore whether the findings may assist in the consideration of surgical treatment for refractory frontal lobe epilepsy. Specifically, we will determine whether there is evidence of abnormal functional and structural connectivity of the frontal lobes and whether that predicts the cognitive and psychological deficits that may occur after surgery to the frontal lobes. The combination of cognitive fMRI, tractography and comprehensive neuropsychological assessment pre- and postoperatively represents an unique opportunity to improve understanding of the imaging correlates of neuronal circuits, and the effects of these epilepsysyndromes on cognition.

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Grant Details

Amount Awarded 244430
Applicant Surname Koepp
Approval Committee Cognitive and Higher Systems Funding Committee
Award Date 2006-05-10T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Project Grant
Internal ID 079474/A/06/Z
Lead Applicant Prof Matthias Koepp
Other Applicant(s) Dr Mark Symms, Dr P Thompson, Prof Gareth Barker, Prof John Duncan, Prof Veena Kumari
Partnership Value 244430
Planned Dates: End Date 2010-09-30T00:00:00+00:00
Planned Dates: Start Date 2007-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London