Multiplex analysis of genes and proteins in human disease. (360G-Wellcome-079670_Z_06_Z)
This application requests part funding for real-time PCR and Luminex bead array equipment, to support several research groups who are focussing on the molecular pathogenesis of human disease utilising patient- and population-based approaches underpinned by proof of concept laboratory biomedical studies. The following research programmes will be supported: (1) Role of epithelial and endothelial barrier dysfunction in the pathogenesis of inflammatory bowel disease and the development of sepsis. (2) Inflammatory responses in the brain and their role in the pathology of stroke and Alzheimers disease. (3) Identification of genetic markers and cellular processes involved in micro-and macrovascular disease. (4) Identification of genetic risk factors in neurodegenerative disease. The primary goals common to all these programmes are: (i) understanding the molecular basis of disease pathogenesis, (ii) investigating how biomarkers can be used to inform the diagnosis and management of di sease and (ii) to identify new therapeutic targets. Understanding these complex pathologies at the molecular level depends increasingly on the ability to rapidly quantify multiple genes, proteins and other biomarkers at levels sensitive enough to allow translation into clinical settings. The requested equipment will provide such facilities and, greatly enhance not only existing programmes of research but also new and emerging areas.
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Grant Details
Amount Awarded | 47099 |
Applicant Surname | Warhurst |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2006-04-27T00:00:00+00:00 |
Financial Year | 2005/06 |
Grant Programme: Title | Equipment & Resources: Inactive Scheme |
Internal ID | 079670/Z/06/Z |
Lead Applicant | Prof Geoff Warhurst |
Other Applicant(s) | Dr David Mann, Dr Stephen Hopkins, Prof John Gibson |
Partnership Value | 47099 |
Planned Dates: End Date | 2009-04-30T00:00:00+00:00 |
Planned Dates: Start Date | 2006-05-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | North West |