Multiplex analysis of genes and proteins in human disease. (360G-Wellcome-079670_Z_06_Z)

£47,099

This application requests part funding for real-time PCR and Luminex bead array equipment, to support several research groups who are focussing on the molecular pathogenesis of human disease utilising patient- and population-based approaches underpinned by proof of concept laboratory biomedical studies. The following research programmes will be supported: (1) Role of epithelial and endothelial barrier dysfunction in the pathogenesis of inflammatory bowel disease and the development of sepsis. (2) Inflammatory responses in the brain and their role in the pathology of stroke and Alzheimers disease. (3) Identification of genetic markers and cellular processes involved in micro-and macrovascular disease. (4) Identification of genetic risk factors in neurodegenerative disease. The primary goals common to all these programmes are: (i) understanding the molecular basis of disease pathogenesis, (ii) investigating how biomarkers can be used to inform the diagnosis and management of di sease and (ii) to identify new therapeutic targets. Understanding these complex pathologies at the molecular level depends increasingly on the ability to rapidly quantify multiple genes, proteins and other biomarkers at levels sensitive enough to allow translation into clinical settings. The requested equipment will provide such facilities and, greatly enhance not only existing programmes of research but also new and emerging areas.

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Grant Details

Amount Awarded 47099
Applicant Surname Warhurst
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2006-04-27T00:00:00+00:00
Financial Year 2005/06
Grant Programme: Title Equipment & Resources: Inactive Scheme
Internal ID 079670/Z/06/Z
Lead Applicant Prof Geoff Warhurst
Other Applicant(s) Dr David Mann, Dr Stephen Hopkins, Prof John Gibson
Partnership Value 47099
Planned Dates: End Date 2009-04-30T00:00:00+00:00
Planned Dates: Start Date 2006-05-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West