Descending Serotonergic Control and Neuropathic Pain. (360G-Wellcome-080506_Z_06_Z)

£366,903

There is now compelling evidence that the maintenance of pain states is dependent on descending facilitation from the brainstem. This facilitation is in part serotonergic and derived from a subset of neurons located in the rostroventral medulla. Ablation of spinal serotonin attenuates peripheral neuropathic pain states in rats. Our first goal is to establish that the serotonergic pathway is distinct from other descending facilitatory pathways. The second goal is to monitor the dynamics of serot onergic activity in normal and neuropathic rats by measuring i) the evoked and spontaneous activity of superficial dorsal horn projection neurons and ii) the influence of serotonin and serotonin receptor antagonists on projection neuron activity. The third related goal will be to monitor changes in serotonergic tone in the dorsal horn of neuropathic rats using microdialysis. Finally, we will apply this data to our research into the activity of the 5HT pathway in mouse models of pancreatic and bone cancer pain where the regulation of 5HT synthesis in the rostroventral medulla appears to be directly correlated with the appearance of the pain state.

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Grant Details

Amount Awarded 366903
Applicant Surname Hunt
Approval Committee Molecular and Cellular Neuroscience Funding Committee
Award Date 2006-10-12T00:00:00+00:00
Financial Year 2006/07
Grant Programme: Title Project Grant
Internal ID 080506/Z/06/Z
Lead Applicant Prof Stephen Hunt
Other Applicant(s) Prof Anthony Dickenson
Partnership Value 366903
Planned Dates: End Date 2010-10-31T00:00:00+00:00
Planned Dates: Start Date 2007-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London