Role of cell surface proteins in the pathogenesis of Clostridium difficile. (360G-Wellcome-080555_Z_06_A)
The aim of this project is to define C. difficile genes and gene products essential for adherence to host tissues. The objectives are: 1. To establish a robust model of adhesion of C. difficile to the cultured enteric CaCo2 cell line. 2. To further study adhesion using in vitro organ cultures of hamster gut. 3. To create knock-out mutants of defined genes in C. difficile and to analyse their behaviour in the adhesion models of the bacterium with host tissues. Genes and gene products identified as important for adhesion will be further studied using molecular and biochemical techniques.
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Grant Details
| Amount Awarded | 869 |
| Applicant Surname | Reynolds |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2008-04-15T00:00:00+00:00 |
| Financial Year | 2007/08 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 080555/Z/06/A |
| Lead Applicant | Ms Catherine Reynolds |
| Partnership Value | 869 |
| Planned Dates: End Date | 2010-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2008-04-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Martin Allday |