A model of postnatal tissue regeneration from transplanted stem cells. (360G-Wellcome-081271_Z_06_Z)
Our key goals are to determine which subpopulations of mouse and human satellite cells are the best muscle stem cells and whether non-satellite cells can contribute efficiently to skeletal muscle regeneration. We will also determine optimal environmental conditions for skeletal muscle regeneration from transplanted satellite or stem cells. We wish to use our model of skeletal muscle formation in vivo from transplanted cells to test the efficacy of potential treatments of Duchenne muscular d ystrophy on human muscle in vivo. We will determine the role of nitric oxide in either preventing or reducing intestinal damage in a rat model of necrotizing enterocolitis. We will also determine the role of stem cells in enhancing tissue repair in necrotizing enterocolitis.
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Grant Details
Amount Awarded | 164508 |
Applicant Surname | Pierro |
Approval Committee | Physiological Sciences Funding Committee |
Award Date | 2006-11-09T00:00:00+00:00 |
Financial Year | 2006/07 |
Grant Programme: Title | Equipment & Resources: Inactive Scheme |
Internal ID | 081271/Z/06/Z |
Lead Applicant | Prof Agostino Pierro |
Other Applicant(s) | Dr Susan Brown, Prof Francesco Muntoni, Prof Jennifer Morgan, Prof Ketan Patel |
Partnership Value | 164508 |
Planned Dates: End Date | 2013-06-30T00:00:00+00:00 |
Planned Dates: Start Date | 2008-07-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |