A model of postnatal tissue regeneration from transplanted stem cells. (360G-Wellcome-081271_Z_06_Z)

£164,508

Our key goals are to determine which subpopulations of mouse and human satellite cells are the best muscle stem cells and whether non-satellite cells can contribute efficiently to skeletal muscle regeneration. We will also determine optimal environmental conditions for skeletal muscle regeneration from transplanted satellite or stem cells. We wish to use our model of skeletal muscle formation in vivo from transplanted cells to test the efficacy of potential treatments of Duchenne muscular d ystrophy on human muscle in vivo. We will determine the role of nitric oxide in either preventing or reducing intestinal damage in a rat model of necrotizing enterocolitis. We will also determine the role of stem cells in enhancing tissue repair in necrotizing enterocolitis.

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Grant Details

Amount Awarded 164508
Applicant Surname Pierro
Approval Committee Physiological Sciences Funding Committee
Award Date 2006-11-09T00:00:00+00:00
Financial Year 2006/07
Grant Programme: Title Equipment & Resources: Inactive Scheme
Internal ID 081271/Z/06/Z
Lead Applicant Prof Agostino Pierro
Other Applicant(s) Dr Susan Brown, Prof Francesco Muntoni, Prof Jennifer Morgan, Prof Ketan Patel
Partnership Value 164508
Planned Dates: End Date 2013-06-30T00:00:00+00:00
Planned Dates: Start Date 2008-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London