The molecular mechanisms of activation of G-protein gated inwardly rectifying K+ channels (360G-Wellcome-081475_Z_06_Z)
The hypothesis I would like to examine is "In atrial myocytes the inhibitory G-protein subunit nucleates the formation of a signalling complex of a dimeric G-protein coupled receptor (GPCR), for example the M2 muscarinic receptor, heterotrimeric G-protein, regulators of G-protein signalling and G-protein gated K+ channel." Specifically the goals are Goal 1:- To examine for M2 muscarinic, A1 adenosine and S1P3 sphingosine-1-phosphate receptor dimerisation and to delineate the molecular determinants and consequences of oligomerisation in native atrial myocytes. Goal 2:- To determine if a complex exists of GPCR with Gi\o-protein heterotrimers and with GIRK channels prior to agonist exposure and what happens to the complex in the presence of agonist. Goal 3:- To examine the role of individual Gi\o isoforms and RGSs, in particular RGS3, RGS4 and RGS5, in signalling to GIRK channels in native atrial myocytes.
Where is this data from?
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Grant Details
Amount Awarded | 1039333 |
Applicant Surname | Tinker |
Approval Committee | Physiological Sciences Funding Committee |
Award Date | 2007-02-22T00:00:00+00:00 |
Financial Year | 2006/07 |
Grant Programme: Title | Programme Grant |
Internal ID | 081475/Z/06/Z |
Lead Applicant | Prof Andrew Tinker |
Partnership Value | 1039333 |
Planned Dates: End Date | 2011-08-31T00:00:00+00:00 |
Planned Dates: Start Date | 2007-09-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |