The role of haematopoietic lineage cells in the TMEV model of multiple sclerosis. (360G-Wellcome-083135_Z_07_B)

£13,694

This proposal addresses the role of haematopoietic lineage cells (HCs) in disease persistence and spread in a viral model of multiple sclerosis (MS). We hope to determine the cell type and route of entry of HCs into the central nervous system (CNS) using a combination of immunohistochemistry, molecular biology and 2-photon slice imaging. Using molecular biology techniques we will investigate the mechanistic hypothesis that galectin-3 is necessary for Theiler's murine encephalitis virus (TMEV) induced HC recruitment and migration.

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Grant Details

Amount Awarded 13694
Applicant Surname James
Approval Committee Neurosciences And Mental Health
Award Date 2011-08-31T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title PhD Studentship (Basic)
Internal ID 083135/Z/07/B
Lead Applicant Miss Rachel James
Partnership Value 13694
Planned Dates: End Date 2011-09-30T00:00:00+00:00
Planned Dates: Start Date 2011-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East
Sponsor(s) Prof Andrew King