Student electives for Mostayn Alam and James Myerscough. (360G-Wellcome-083430_Z_07_Z)

Hydrocephalus is a condition in which abnormal accumulation of cerebrospinal fluid (CSF) in the brain causes increased intracranial pressure inside the skull. This is usually due to blockage of CSF outflow in the brain ventricles or in the subarachnoid space at the base of the brain. Chronic hydrocephalus (CH) is characterized by increased cerebrospinal fluid volume with or without increased intracranial pressure (ICP), and often associated with impaired cognition thought to be related to decrease cerebral blood flow and oxygen delivery. In hydrocephalus, increased ICP and vascular compression as the result of enlarged ventricles may be directly responsible. VEGF plays a critical role in angiogenesis, neuronal protection as it relates to ischemic/hypoxic events.