The neural basis of spatial and episodic memory in humans. (360G-Wellcome-084218_Z_07_A)

£1,037,451

A distributed set of brain regions supports episodic memory, the memory for personal experiences. This brain network overlaps considerably with that associated with navigation and imagination. Surprisingly little is understood about the contributions individual brain areas within this network make in subserving these vital yet distinct cognitive functions. The goal of my research is to understand how these common brain areas, and possibly common processes, underpin episodic memory, navigation an d imagination. To examine this I will study healthy subjects and patients with non-progressive pathologies using fMRI and neuropsychological testing. As well as commonalities I will investigate differences, exploring which additional brain regions are co-opted into this common network to support operations unique to specific functions such as episodic memory. I will complement this systems level approach with a focussed examination of a key region within the common brain network, namely the hip pocampus, as damage to it has the greatest impact on the memory system. I will seek to establish what kind of information it represents using new high resolution imaging and multivariate decoding techniques. I believe that functionally deconstructing the memory system in this way will provide novel and fundamental insights into the mechanisms involved in coding our experiences.

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Grant Details

Amount Awarded 1037451
Applicant Surname Maguire
Approval Committee Basic Science Interview Committee
Award Date 2008-04-09T00:00:00+00:00
Financial Year 2007/08
Grant Programme: Title Senior Research Fellowship Basic Renewal
Internal ID 084218/Z/07/A
Lead Applicant Prof Eleanor Maguire
Partnership Value 1037451
Planned Dates: End Date 2014-09-30T00:00:00+00:00
Planned Dates: Start Date 2008-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Raymond Dolan