Regulation and transduction of cell polarity. (360G-Wellcome-084598_Z_07_Z)
Cell polarity is critical for many functions of animal cells and loss of cell polarity is a contributing factor in cancer. We are exploiting the one-celled C. elegans embryo to investigate conserved mechanisms of cell polarity establishment and transduction. It allows study of the polarity cue and its reception by the actomyosin cytoskeleton, of the polarisation events that occur in response to the polarity cue, and of how polarisation leads to downstream events such as asymmetric spindle posi tioning. I propose both focused projects that have come out of our current studies and new screens to identify missing molecules in the cell polarity network. We will (1) carry out directed screens to identify the initial polarity cue, (2) study newly identified regulators of non-muscle myosin, and (3) investigate roles for phosphoinositides in asymmetric spindle positioning. With a long-term goal of finding the complete set of genes functioning in these processes and their relationships, we w ill (4) apply high-throughput genetic interaction RNAi screening genome-wide together with (5) biochemical purifications to further expand the cell polarity network. (6) We will carry out functional studies of newly identified genes, taking advantage of C.elegans genetics, genomics and cell biology.
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Grant Details
Amount Awarded | 2842255 |
Applicant Surname | Ahringer |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2008-02-20T00:00:00+00:00 |
Financial Year | 2007/08 |
Grant Programme: Title | Senior Research Fellowship Basic Renewal |
Internal ID | 084598/Z/07/Z |
Lead Applicant | Prof Julie Ahringer |
Partnership Value | 2842255 |
Planned Dates: End Date | 2014-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2008-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Sir Jim Smith |