Genome-wide association studies in partial epilepsies. (360G-Wellcome-084730_Z_08_Z)

£1,375,065

scientifically qualified assessors (no more than 200 words): Genome-wide association studies (GWAS) are daily advancing understanding across human diseases, with enormous potential for disease prevention, generation of novel treatments and better use of existing treatments. We propose contemporary, potent GWAS to reveal genetic contributions to specific phenotypes in the partial epilepsies, which are the most common epilepsy type, representing the bulk of disease burden. We have already undertaken extensive genomics research. Experience, including our own, has enabled formulation of a successful strategy which we intend to apply to our multinational patient cohort collection established through an international collaborative consortium in epilepsy genomics. Our collaboration includes industry, with samples from GlaxoSmithKline collection, and funding contribution from GSK contingent on successful funding of the application. For this application, we have assembled a large cohort of well-characterised patients with partial epilepsy, secured access to even more patients, and established and applied consortium-wide definitions for disease and seizure types. Our published genotyping, association and post-association follow-up strategies, validating both our cohorts and our general approach, will be applied. Our key goals are to identify common genetic risk factors for disease susceptibility and seizure generalisation in the partial epilepsies and to generate a large genotype dataset for further studies.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 1375065
Applicant Surname Sisodiya
Approval Committee Genome-Wide Association Studies in Common Disease Committee 2008
Award Date 2008-01-12T00:00:00+00:00
Financial Year 2007/08
Grant Programme: Title Programme Grant
Internal ID 084730/Z/08/Z
Lead Applicant Prof Sanjay Sisodiya
Other Applicant(s) Norman Delanty, Prof David Goldstein, Prof Giuliano Avanzini, Prof Josemir Sander, Prof Michael Johnson, Prof Nicholas Wood
Partnership Value 1375065
Planned Dates: End Date 2014-07-31T00:00:00+00:00
Planned Dates: Start Date 2008-03-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London