Computational studies of the usher outer-membrane assembly platform involved in pilus biogenesis. (360G-Wellcome-086711_Z_08_Z)
a. Model the complete usher structure (dimeric form) from p pili in its native environment (periplasm and OM) using tools such as cryo-electron microscopy density fitting, homology modelling and solvation methods. b. Apply standard molecular dynamics (MD) simulations on various components of the usher within their native environment. c. Use SMD and ABF methods to understand and quantify the conformational changes that occur in the usher protein upon translocation of pili subunits across the membrane. d. Develop a web-based resource that will summarize all the experimental and computational structural and biophysical data on the p and type 1 pi lis systems.
Where is this data from?
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Grant Details
| Amount Awarded | 148911 |
| Applicant Surname | Farabella |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2008-08-29T00:00:00+00:00 |
| Financial Year | 2007/08 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 086711/Z/08/Z |
| Lead Applicant | Miss Irene Farabella |
| Partnership Value | 148911 |
| Planned Dates: End Date | 2012-09-21T00:00:00+00:00 |
| Planned Dates: Start Date | 2008-09-22T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Gabriel Waksman |