A proposal for the determination of small molecule messages: the enigma of signalling in olfaction. (360G-Wellcome-088982_Z_09_Z)
The proposed research is to determine the signal transduction process in olfaction, and in turn hopefully to develop a generic model for other ligand-protein interactions. The physical processes will be established by creation of a RealNose where human olfactory receptors are stabilized onto a biochip and the signal response from various activating odorants will be read out. The creation of this device will not only provide the parameters for modelling data, but involves key stages of scientif ic interest, such as: i) The expression, stabilization and crystallography of G-protein coupled receptors (the olfactory receptors). ii) Determination of the stimuli required across receptor type activation, resolving the affinity/efficacy issue, troublesome in many drug-receptor systems, through assay information and Surface Plasmon Resonance. iii) Determination of the processes in this unique membrane protein, such as conformational changes and the importance there of. iv) Identifying t he processes involved in a complex combinatorial process from signal initiation to perception: a pattern recognition issue.
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Grant Details
Amount Awarded | 250000 |
Applicant Surname | Brookes |
Approval Committee | Sir Henry Wellcome Postdoctoral Fellowships Interview Committee |
Award Date | 2009-05-27T00:00:00+00:00 |
Financial Year | 2008/09 |
Grant Programme: Title | Sir Henry Wellcome Postdoctoral Fellowship |
Internal ID | 088982/Z/09/Z |
Lead Applicant | Dr Jennifer Brookes |
Partnership Value | 250000 |
Planned Dates: End Date | 2013-10-04T00:00:00+00:00 |
Planned Dates: Start Date | 2009-10-05T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Andrew Fisher |