A proposal for the determination of small molecule messages: the enigma of signalling in olfaction. (360G-Wellcome-088982_Z_09_Z)

£250,000

The proposed research is to determine the signal transduction process in olfaction, and in turn hopefully to develop a generic model for other ligand-protein interactions. The physical processes will be established by creation of a RealNose where human olfactory receptors are stabilized onto a biochip and the signal response from various activating odorants will be read out. The creation of this device will not only provide the parameters for modelling data, but involves key stages of scientif ic interest, such as: i) The expression, stabilization and crystallography of G-protein coupled receptors (the olfactory receptors). ii) Determination of the stimuli required across receptor type activation, resolving the affinity/efficacy issue, troublesome in many drug-receptor systems, through assay information and Surface Plasmon Resonance. iii) Determination of the processes in this unique membrane protein, such as conformational changes and the importance there of. iv) Identifying t he processes involved in a complex combinatorial process from signal initiation to perception: a pattern recognition issue.

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Grant Details

Amount Awarded 250000
Applicant Surname Brookes
Approval Committee Sir Henry Wellcome Postdoctoral Fellowships Interview Committee
Award Date 2009-05-27T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Sir Henry Wellcome Postdoctoral Fellowship
Internal ID 088982/Z/09/Z
Lead Applicant Dr Jennifer Brookes
Partnership Value 250000
Planned Dates: End Date 2013-10-04T00:00:00+00:00
Planned Dates: Start Date 2009-10-05T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Andrew Fisher