Cellular and network mechanisms of pattern separation in the dentate gyrus. (360G-Wellcome-089265_Z_09_A)
This project will investigate how hippocampal dentate gyrus granule cells process synaptic inputs from the medial and lateral entorhinal cortex (MEC and LEC). I will determine how particular activity patterns in MEC and LEC are translated into granule cell population activity in vitro by selectively activating neurons in MEC and LEC using optogenetic stimulation of presynaptic neurons. The results of these experiments will be used to help us interpret subsequent in vivo recordings from granule cells in awake mice navigating in a virtual reality (VR) environment. Both in vitro and in vivo data will be used to construct models to help us to understand the link between cellular processing and behavioural pattern separation.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 11835 |
Applicant Surname | Toleikyte |
Approval Committee | Neurosciences And Mental Health |
Award Date | 2011-06-06T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 089265/Z/09/A |
Lead Applicant | Ms Gabija Toleikyte |
Partnership Value | 11835 |
Planned Dates: End Date | 2013-09-27T00:00:00+00:00 |
Planned Dates: Start Date | 2011-06-28T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof David Attwell |