Cellular and network mechanisms of pattern separation in the dentate gyrus. (360G-Wellcome-089265_Z_09_A)

£11,835

This project will investigate how hippocampal dentate gyrus granule cells process synaptic inputs from the medial and lateral entorhinal cortex (MEC and LEC). I will determine how particular activity patterns in MEC and LEC are translated into granule cell population activity in vitro by selectively activating neurons in MEC and LEC using optogenetic stimulation of presynaptic neurons. The results of these experiments will be used to help us interpret subsequent in vivo recordings from granule cells in awake mice navigating in a virtual reality (VR) environment. Both in vitro and in vivo data will be used to construct models to help us to understand the link between cellular processing and behavioural pattern separation.

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Grant Details

Amount Awarded 11835
Applicant Surname Toleikyte
Approval Committee Neurosciences And Mental Health
Award Date 2011-06-06T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title PhD Studentship (Basic)
Internal ID 089265/Z/09/A
Lead Applicant Ms Gabija Toleikyte
Partnership Value 11835
Planned Dates: End Date 2013-09-27T00:00:00+00:00
Planned Dates: Start Date 2011-06-28T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof David Attwell