Role of c-jun in damage to neonatal central nervous system. (360G-Wellcome-089624_Z_09_Z)
For scientifically qualified assessors (no more than 200 words) The key research goals will be to: (A) determine the full scale of c-Jun effects on white and grey matter damage following hypoxic-ischemic insult and the functional repair, using neural deletion of floxed jun gene with nestin:.cre recombinase (B) explore, whether c-Jun and/or the JNKs are involved in mediating the synergy between infectious and HI stimuli in mediating the neonatal injury (C) indentify, which of the c-Jun expres sing cells (neurons, astrocytes, oligodendroglia and their precursors, or microglia) act as a pacemaker, in mediating c-Jun dependent, HI neonatal brain damage, using cell-type specific promoters for cre recombinase (syn::cre, gfap::cre, plp::cre, mac1::cre). (D) assess, whether these effects require or do not require JNK-dependent Jun phosphorylation using blood-brain permeable JNK inhibitors SP600125 and DJNKI1, AND whether these inhibitors exhibit additional c-Jun independent effects
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Grant Details
| Amount Awarded | 278118 |
| Applicant Surname | Raivich |
| Approval Committee | Molecular and Cellular Neuroscience Funding Committee |
| Award Date | 2009-10-08T00:00:00+00:00 |
| Financial Year | 2009/10 |
| Grant Programme: Title | Project Grant |
| Internal ID | 089624/Z/09/Z |
| Lead Applicant | Dr Gennadij Raivich |
| Other Applicant(s) | Dr Axel Behrens, Prof Donald Peebles |
| Partnership Value | 278118 |
| Planned Dates: End Date | 2013-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2010-01-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |