Structural studies of the Type III secretion system. (360G-Wellcome-089664_Z_09_Z)
The Type Ill Secretion System (T3SS) is a complex molecular machine that is a key virulence determinant for important Gram-negative pathogens including E. coli, Shigella, Yersinia and Salmonella species. The T3SS consists of multiple copies of 25 different proteins (totalling -7MDa), spans both bacterial membranes and drives insertion of a contiguous pore into the host-cell membrane. Virulence factors are secreted via this apparatus directly into the host cell. This proposal seeks to probe a key stage in regulation of the secretion through a T3SS by investigating the structure and interactions of the so-called gatekeeper protein SepL which, with its interacting partner SepD, is known to control the specificity of effector secretion through the apparatus from the bacterial cytoplasm.
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Grant Details
| Amount Awarded | 152906 |
| Applicant Surname | Rollauer |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2009-05-29T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 089664/Z/09/Z |
| Lead Applicant | Ms Sarah Rollauer |
| Partnership Value | 152906 |
| Planned Dates: End Date | 2013-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof David Stuart |