Investigating changes in hypothalamic gene expression that underpins the loss of counter regulatory defences to hypoglycaemia. (360G-Wellcome-089942_Z_09_A)
Line 1: To identify changes in hypothalamic gene expression that underpin the loss of critical, defensive counter-regulatory responses to hypoglycaemia in type I diabetes mellitus. Line 2: To examine in greater depth the molecular mechanisms identified in line 1, to determine the pathophysiological basis for loss of hypoglycaemic counter-regulation in diabetes. Line 3: To predict and analyse potential therapeutic manipulations of counter-regulatory defences to hypoglycaemia based on pathways identified in line 2 in an animal model of diabetes.
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Grant Details
| Amount Awarded | 49916 |
| Applicant Surname | Marsh |
| Approval Committee | Physiological Sciences Funding Committee |
| Award Date | 2011-03-28T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 089942/Z/09/A |
| Lead Applicant | Mr William Marsh |
| Partnership Value | 49916 |
| Planned Dates: End Date | 2013-10-26T00:00:00+00:00 |
| Planned Dates: Start Date | 2010-10-27T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |
| Sponsor(s) | Prof Sir Stephen O'Rahilly |