CpG island binding proteins: elucidating the function of the histone demethylase KDM2 and the leukemic histone methyltransferase MLL in the zebrafish. (360G-Wellcome-090018_Z_09_A)
The aim of this research proposal is to investigate how the ZF-CxxC domain containing KDM2 and MLL proteins contribute to CpG island function, chromatin modification, and development in the model organism the zebrafish (Dania rerio). 1) To identify zebrafish orthologues of ZF-CxxC KDM2 and MLL proteins and examine their biochemical properties. 2) To perturb the expression of KDM2 and MLL and to analyse the phenotypic consequence during development. 3) To examine mechanistically the domain function of KDM2 and MLL by targeted rescue experiments.
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Grant Details
| Amount Awarded | 35692 |
| Applicant Surname | Long |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2011-02-21T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 090018/Z/09/A |
| Lead Applicant | Dr Hannah Long |
| Partnership Value | 35692 |
| Planned Dates: End Date | 2013-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2010-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof Kim Nasmyth |