Investigation of endothelial cell ICAM-1 signalling pathways and their role in controlling lymphocyte migration to the CNS. (360G-Wellcome-090326_Z_09_Z)

£290,139

The endothelial cells of the brain and retina play an important part in the development of neuroinflammatory lesions as they capture leukocytes from the circulation and support transendothelial migration via mechanisms that require induction of outside-in signalling. The cell adhesion molecule ICAM-1 is believed to be a critical molecule in this setting. Our key goals in this project will be to characterise in greater detail the constituents of the proximal ICAM-1 signalling complex in order to define their contribution to propagation of various downstream signalling pathways. We will investigate the induction of signals initiated through ICAM-1 and putative members of the multi-molecular complex with which it associates and how this regulates lymphocyte diapedesis via the paracellular and transcellular routes. This work will extend significantly our understanding of the inflammatory process in the CNS, reveal potential therapeutic targets and address a number of highly topical and gen eric questions facing researchers in the field of leukocyte recruitment.

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Grant Details

Amount Awarded 290139
Applicant Surname Greenwood
Approval Committee Molecular and Cellular Neuroscience Funding Committee
Award Date 2009-10-08T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title Project Grant
Internal ID 090326/Z/09/Z
Lead Applicant Prof John Greenwood
Partnership Value 290139
Planned Dates: End Date 2015-02-17T00:00:00+00:00
Planned Dates: Start Date 2010-05-18T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London