Optimising antimalarial combination therapies in an area coendemic for vivax and falciparum malaria (360G-Wellcome-091625_Z_10_B)

£107,663

I have established a large network of researchers, service providers, and policy makers in Papua, Indonesia to undertake a series of epidemiological, clinical, and laboratory studies to optimise the treatment and prevention of malaria. Previous studies led to a district-wide (population 180,000) change in policy for uncomplicated malaria to artemisinin combination therapy in 2006. The current proposal will expand our research agenda to address the next phase of ACT deployment, notably an underst anding of the co-factors that determine its impact and cost-effectiveness and how these differentially affect P. falciparum and P. vivax. Novel and complementary studies are planned to optimise the treatment of vivax relapses, improve the diagnosis of G6PD deficiency and develop genetic tools for monitoring drug resistance. This research will provide the evidence base upon which to optimise malaria control programmes. The crucial involvement of collaborative partners in the District Health Au thority, local government and Indonesian National CDC will ensure that the results of the project impact directly on MoH policy decisions not only for Papua but also elsewhere in Indonesia. My objective is that these tools will be endorsed by WHO and adopted by the current global elimination efforts.

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Grant Details

Amount Awarded 107663
Applicant Surname Price
Approval Committee Science Interview Panel
Award Date 2015-07-07T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Senior Research Fellowship Clinical
Internal ID 091625/Z/10/B
Lead Applicant Prof Richard Price
Partnership Value 107663
Planned Dates: End Date 2016-08-30T00:00:00+00:00
Planned Dates: Start Date 2015-08-31T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East