Wellcome Trust Joint Basic and Clinical PhD Programme at the University of Birmingham: 'Regulation of germinal centre derived plasma cell differentiation'. (360G-Wellcome-091693_Z_10_A)
The role of IL-22 for plasma cell output from germinal centre. (a) Aims: Germinal centres (GC) are the sites where high affinity antibody and B cell memory develop. The signals directing differentiation of GC B cells are not clear. We have recently identified IL22 as a factor influencing plasma cell differentiation from GCs. IL22 deficient mice produce larger clusters of GC associated plasmablasts upon immunization. The project will define the mechanism, by which IL22 regulates GC B cell differentiation, and will investigate whether IL22 has other effects on B cell differentiation. Understanding a role of IL22 for GC B cell differentiation may lead to ways to manipulate antibody responses to vaccines, pathogens, or autoantigens.
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Grant Details
| Amount Awarded | 47585 |
| Applicant Surname | George |
| Approval Committee | Neurosciences And Mental Health |
| Award Date | 2010-12-14T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | PhD Studentship (Basic & Clinical) |
| Internal ID | 091693/Z/10/A |
| Lead Applicant | Miss Laura George |
| Partnership Value | 47585 |
| Planned Dates: End Date | 2013-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2010-12-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | West Midlands |
| Sponsor(s) | Prof John Gordon, Prof Paul Stewart |