Support for a Wellcome Trust/Academy of Medical Sciences Internship. (360G-Wellcome-093568_Z_10_A)
Aim 1: To examine preference for, and rewarding properties, of dietary fat. Aim 2: To examine preference for, and rewarding properties of, sucrose. Aim 3: To determine whether preference for dietary sucrose and fat is mediated melanocortin signalling. Aim 4: To examine the brain activation response to manipulation of single/multiple diet macronutrients. 1. Increased dietary fat content in food will increase the preference for and rewarding properties of the food. Increasing fat content in food will be positively correlated with brain activation of areas involved in reward. 2. Increased sucrose content in food will increase the preference for and rewarding properties of the food. Rewarding properties and preference for food containing artificial sweetener in place of sucrose will be reduced compared to matched sucrose formed contents. Increasing sucrose content in food will be positively correlated with brain activation of areas involved in reward. 3. MC4R deficient subjects will display an increased preference for high-fat food (but not high sucrose food) in comparison to equally obese subjects matched for age.
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Grant Details
| Amount Awarded | 5655 |
| Applicant Surname | Medic |
| Approval Committee | PhD Studentships |
| Award Date | 2014-10-27T00:00:00+00:00 |
| Financial Year | 2014/15 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 093568/Z/10/A |
| Lead Applicant | Mr Nenad Medic |
| Partnership Value | 5655 |
| Planned Dates: End Date | 2014-12-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2014-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |
| Sponsor(s) | Prof Sir Stephen O'Rahilly |