PPE application: Researchers and Media for Public Engagement on Sickle Cell Disease in Tanzania. (360G-Wellcome-093727_Z_10_B)

Severe anaemia is a major cause of morbidity and mortality in SCA. HbF is a major factor influencing anaemia, BT requirement and outcome. There is no information on HbF in East Africa. I propose to examine the association of HbF and severe anaemia in Tanzanian SCA patients. BT is the mainstay of management but concerns about safety, supply and cost have prompted a search for alternative interventions. Hydroxyurea is used in SCA in North America and Europe; effectively reducing morbidity (pain , hospitalisation, BT) and mortality. Its main efficacy is increasing HbF levels, but this has not been consistently reported. Other mechanisms include reduced inflammation and vasculopathy. There is inadequate information on its efficacy, mechanism of action and safety in Africa as it would be an alternative for BT. I will describe the response to hydroxyurea in SCA; determine the toxicity, optimal dosing and monitoring regime. In identifying patients for hydroxyurea treatment, I will dete rmine and treat known causes of severe anaemia such as infections (malaria, bacteraemia, parvovirus), splenic sequestration and nutritional deficiency (folic acid, vitamin A, B12, iron). This fellowship will provide the evidence on HbF and hydroxyurea required to conduct clinical trials and improve management of severe anaemia.

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Grant Details

Amount Awarded 59116
Applicant Surname Makani
Approval Committee Board of Governors
Award Date 2015-06-22T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Provision for Public Engagement
Internal ID 093727/Z/10/B
Lead Applicant Prof Julie Makani
Partnership Value 59116
Planned Dates: End Date 2017-03-31T00:00:00+00:00
Planned Dates: Start Date 2015-08-01T00:00:00+00:00
Recipient Org: Country Tanzania
Region International