Wellcome Trust Clinical PhD Programme at the University of Dundee. (360G-Wellcome-093989_Z_10_Z)

£227,413

Parkinson Disease (PD) is the second most common neurodegenerative disorder after Alzheimer Disease with significant burdens on individuals, their families, and on society. The discovery that PD follows Mendelian inheritance patterns in some families has led to the identification of PD associated genes. As sporadic and monogenetic Parkinsonism share important neuropathological and clinical features, notably the susceptibility of dopaminergic neurons in the substantia nigra to cell damage, insight into the function of disease causing gene mutations is expected to promote our understanding of key regulatory pathways involved in PD neurodegeneration. Mutations in the Fbxo7 gene have recently been linked to a complex, young-onset Parkinsonian syndrome. Little is known about the physiological role of the Fbxo7 protein or how mutations results in PD-associated neurodegeneration. The aim of my research project is to elucidate the signal transduction pathway of Fbxo7 utilizing standard and human-derived, patient-specific cell lines, but also by generating a new mouse model with human disease-associated knock in and conditional knock-out mutations of the Fbxo7 gene. It is hoped that the findings of the proposed project contribute to a better understanding of PD pathogenesis, the development of new treatment options and possibly the availability of a valid PD mouse model.

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Grant Details

Amount Awarded 227413
Applicant Surname Sammler
Approval Committee Neurosciences And Mental Health
Award Date 2010-08-31T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title PhD Training Fellowship for Clinicians
Internal ID 093989/Z/10/Z
Lead Applicant Dr Esther Sammler
Partnership Value 227413
Planned Dates: End Date 2014-04-05T00:00:00+00:00
Planned Dates: Start Date 2010-09-06T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland
Sponsor(s) Prof Doreen Cantrell