Wellcome Trust Clinical PhD Programme at the University of Dundee. (360G-Wellcome-093991_Z_10_Z)

£220,113

Reduced tissue sensitivity to insulin, called insulin resistance (IR), is a major feature of Type 2 Diabetes (T2DM). It also develops many years in advance before T2DM. The majority of the health problems associated with diabetes, such as vascular disease, are likely to begin to develop during insulin resistance. Therefore, it is important to understand why and how insulin resistance develops and how it progresses to diabetes and its complications in some people but not others. Insulin reduces hepatic glucose output in large part by repressing transcription of specific genes, but this process is defective in IR and T2DM. We will generate a transgenic mouse expressing a reporter peptide under the control of a key insulin-regulated gene promoter to investigate hepatic IR and its role in development of T2DM. This peptide is secreted into the blood and urine, and is quantified by ELISA. Therefore peptide levels will be directly related to promoter activity and hence be a surrogate of IR. Peptide measurements will be compared with current methods of assessing IR, including gold standard hormone clamp studies. The novel mouse will be made available, for crossing with models of diabetes, providing a non-invasive, accurate technique for the assessment of IR in vivo. These tools will improve research into the development of IR and T2DM.

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Grant Details

Amount Awarded 220113
Applicant Surname Patel
Approval Committee Neurosciences And Mental Health
Award Date 2010-08-31T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title PhD Training Fellowship for Clinicians
Internal ID 093991/Z/10/Z
Lead Applicant Dr Kashyap Patel
Partnership Value 220113
Planned Dates: End Date 2013-09-05T00:00:00+00:00
Planned Dates: Start Date 2010-09-06T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland
Sponsor(s) Prof Doreen Cantrell