Neuronal integration in sensory cortex: New paths to discovery. (360G-Wellcome-095669_Z_11_A)

£160,000

The cortex is known to process images and sounds through the activity of neurons in visual and auditory areas. However, little is known about how cortical populations integrate multiple sensory streams and modalities into coherent pattern, and how sensory-driven activity interacts with non-sensory, endogenous patterns of activity. These patterns may provide the context needed to interpret sensory signals and act upon them. We seek a unified view of how the cortex integrates multiple external and endogenous signals into the activity of neuronal populations. To this end, we will address a series of related questions within a common experimental framework: (1) What is the structure of population activity in sensory areas of the awake cortex? (2) What are the rules of interaction of multiple signals in awake cortex? (3) How does the structure of population responses change with cortical state? (4) How does cortical population activity relate to sensory-driven behavior? (5) What mechanisms control brain state and the structure of population activity? By answering these questions we seek to uncover fundamental laws that predict the population activity from sensory input and internal state, and that predict perceptual choice from population activity, and to provide insight into the underlying circuits and mechanisms.

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Grant Details

Amount Awarded 160000
Applicant Surname Carandini
Approval Committee Science Enhancement Committee
Award Date 2014-04-04T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title Enhancement
Internal ID 095669/Z/11/A
Lead Applicant Prof Matteo Carandini
Partnership Value 160000
Planned Dates: End Date 2017-08-31T00:00:00+00:00
Planned Dates: Start Date 2014-06-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London