Molecular mechanisms regulating the kinetochore-microtubule interaction in mitosis. (360G-Wellcome-096535_Z_11_Z)

£3,848,259

To maintain their genetic integrity, eukaryotic cells must segregate their chromosomes properly to opposite poles during mitosis. The unravelling of the mechanisms that ensure high-fidelity chromosome segregation should improve our understanding of various human diseases such as cancers and congenital disorders (e.g. Down syndrome), which are characterized by chromosome instability and aneuploidy. Sister chromatid segregation during mitosis mainly depends on the forces generated by microtubules that attach to kinetochores. For proper chromosome segregation, kinetochores must interact with spindle microtubules efficiently and this interaction must develop correctly to achieve proper chromosome segregation in the subsequent anaphase. Our research goal is to discover and characterize the molecular mechanisms by which cells regulate these vital processes of kinetochore-microtubule interactions. We investigate the kinetochore-microtubule interactions in budding yeast because of the amenable genetics and detailed proteomic information in this organism. The basic principles of kinetochore-microtubule interactions are similar in yeast and vertebrate cells. Because of this conservation of basic mechanisms, it is likely that results from the yeast system will be of direct relevance to chromosome segregation mechanisms in human cells.

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Grant Details

Amount Awarded 3848259
Applicant Surname Tanaka
Approval Committee Principal Research Fellowship Interview Committee
Award Date 2011-12-06T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title Principal Research Fellowship (New)
Internal ID 096535/Z/11/Z
Lead Applicant Prof Tomoyuki Tanaka
Partnership Value 3848259
Planned Dates: End Date 2021-04-30T00:00:00+00:00
Planned Dates: Start Date 2012-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland
Sponsor(s) Prof Angus Lamond