The role of CNTNAP2 in the Cerebellum (360G-Wellcome-096585_Z_11_Z)
The cerebellum is increasingly implicated in higher cognitive function and cerebellar dysfunction has been linked to several diseases. Recently, there has been accumulating evidence for the involvement of the cerebellum in autism. Cntnap2 -/- mice have been described as a model of autism. In this project, I aim to investigate Cntnap2 function in the cerebellum. I will analyse its cerebellar expression patterns during development and aim to elucidate its role at the synapse of parallel fibres. I will test whether Cntnap2 -/- mice also display a cerebellar behavioural phenotype in addition to the previously described autism-like phenotype. Finally, I aim to rescue Cntnap2 expression in cerebellar granule cells by crossing the Cntnap2 knockout mice with Math1-Cntnap2 transgenic mice and asses motor and autism-like behaviour
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Amount Awarded | 155726 |
| Applicant Surname | Winter |
| Approval Committee | PhD Studentships |
| Award Date | 2011-07-12T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 096585/Z/11/Z |
| Lead Applicant | Ms Friederike Winter |
| Partnership Value | 155726 |
| Planned Dates: End Date | 2016-05-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2011-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof Andrew King |