Characterisation of 18F-NaF as a novel marker for vascular calcification, and development of new treatment strategies for soft tissue mineralisation (360G-Wellcome-096823_Z_11_A)
Arterial calcification is a process that involves calcium deposition in vessel walls. Mineralization is often found in human atherosclerosis, and a recent report suggests that coronary artery calcium scoring serves as a superior predictor of cardiovascular events. 18F-NaF has been proposed as a reliable marker of vascular calcification. However, it is currently unclear which molecular mechanism are detected using this molecule, which biological processes are involved, and how this informs on plaque rupture risk. To address these issues, we have proposed three aims: Aim 1 is to evaluate the ability of 18F-NaF to quantify calcification in human ex vivo plaque; Aim 2 is to study animal models that can recapitulate the process of calcification using PET imaging for the assessment of calcification and Aim 3 isto examine whether animal models provide a mechanism to test the ability of drugs to alter the calcification process. Together the fulfilment of these aims will allow us to assess 18F-NaF as a novel marker for vascular calicifcation and cardiovascular risk, and test pharmacological treatments with this model. These findings could have important implications to decrease mortality worldwide.
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Grant Details
Amount Awarded | 1720 |
Applicant Surname | Irkle |
Approval Committee | PhD Studentships |
Award Date | 2013-01-18T00:00:00+00:00 |
Financial Year | 2012/13 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 096823/Z/11/A |
Lead Applicant | Miss Agnese Irkle |
Partnership Value | 1720 |
Planned Dates: End Date | 2015-12-02T00:00:00+00:00 |
Planned Dates: Start Date | 2013-04-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Sir Stephen O'Rahilly |