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Development of a novel bioartificial liver device for the treatment of patients with liver failure (360G-Wellcome-096861_Z_11_A)

In the UK, over 16,000 patients a year die of liver failure. Their livers have the capacity to repair and regenerate, but do not have time to do so. A device temporarily replacing liver function would save lives and reduce the necessity for liver transplantation worldwide. Dr Clare Selden and her team at UCL have developed a prototype 'bio-artificial liver' (BAL) to address this unmet need. Its key element comprises functioning liver cells in an external bioreactor. Plasma from a patient with liver failure will be passed through the bioreactor, contacting the alginate encapsulated liver cells, so that the cells replace those functions that the sick liver cannot perform. The machine will buy time for a patient's liver to improve or, if damage to the liver is irreversible, may buy time until liver transplantation can be arranged. The technology combines alginate encapsulation of a human liver cell line and subsequent culture of the encapsulated cells in a fluidised bed bioreactor - providing a convenient, manipulatable biomass in a form which maximises mass transfer between cells and perfusing plasma. The team have Translation Award funding to complete the design, specification, performance characterisation and manufacture of this fully biocompatible BAL.

£66,434

30 Sep 2016

Grant details
Amount Awarded 66434
Applicant Surname Selden
Approval Committee Internal Decision Panel
Award Date 2016-09-30T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Translation Award
Internal ID 096861/Z/11/A
Lead Applicant Prof Clare Selden
Other Applicant(s) Dr Barry Fuller, Dr Gabor Mucsi, Prof C. Wendy Spearman, Prof Delawir Kahn, Prof Humphrey Hodgson
Planned Dates: End Date 2016-10-28T00:00:00+00:00
Planned Dates: Start Date 2016-06-14T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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