Investigation of the mechanisms used by Vaccinia virus protein C6 to modulate the host immune response and contribute to virus virulence. (360G-Wellcome-097052_Z_11_Z)
This project aims to understand the mechanisms used by Vaccinia virus (VACV) protein C6 to modulate the host immune response. Specifically, how C6 inhibits type I interferon (IFN)- induced gene expression, the function of the interaction between C6 and the cellular protein SMARCc1, and the contribution of different C6 interactions to virulence in vivo. The subset of IFN-induced genes whose expression is altered by C6 will firstlybe determined. Key events in the signalling pathway required for the IFN-dependent induction of gene expression will be analysed in the presence of C6 to determine where inhibition by C6 occurs. SMARCc1 is a component of the mammalian SWI/SNF complex involved in chromatin
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Grant Details
| Amount Awarded | 155810 |
| Applicant Surname | Stuart |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2011-07-12T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 097052/Z/11/Z |
| Lead Applicant | Ms Jennifer Stuart |
| Partnership Value | 155810 |
| Planned Dates: End Date | 2015-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2011-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | East of England |
| Sponsor(s) | Prof Paul Lehner |