Properties of GABAergic inhibition in the prefrontal cortex. (360G-Wellcome-097263_Z_11_Z)
The molecular mechanisms underpinning GABA receptor mediated synaptic and tonic inhibition in the prefrontal cortex (PFC) will be investigated. Dysfunction of the PFC is implicated together with GABA neurotransmission in numerous neurodevelopmental disorders. The main objective of this project is to analyse the basic mechanisms involved in inhibitory transmission in the PFCand understand how these can be modulated by dopaminergic and serotoninergic pathway activation and by neurosteroids. We will target PV-positive GABAergic interneurons and their target pyramidal neurons in layer II/III of the PFC. Inhibitory transmission will be studied using acute and organotypic brain slice preparations as well as dissociated neuronal cell cultures. The underlying mechanisms will be explored using biochemical, chemical, electrophysiological, imaging (single particle tracking), pharmacological and molecular approaches involving mutated GABA receptors and photo-active receptor ligands. Our understanding of inhibition in the PFC will be used in conjunction with mouse models to try and corroborate their significance with
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Grant Details
| Amount Awarded | 157778 |
| Applicant Surname | Herlt |
| Approval Committee | Neurosciences And Mental Health |
| Award Date | 2011-07-12T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 097263/Z/11/Z |
| Lead Applicant | Ms Tanja Herlt |
| Partnership Value | 157778 |
| Planned Dates: End Date | 2015-09-25T00:00:00+00:00 |
| Planned Dates: Start Date | 2011-09-26T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof David Attwell |