Role of non-muscle myosin II in Caenorhabditis elegans stem-like seam cell asymmetric division (360G-Wellcome-097305_Z_11_Z)
Caenorhabditis elegans (C. elegans) stem cell-like seam cells undergo both symmetric and asymmetric divisions during larval development, thus providing a powerful system to study cell proliferation versus differentiation. The aim of my proposed research is to study how C. elegans seam cell asymmetric divisions are regulated. We have obtained preliminary data in which nmy- 2 was knocked down by RNAi, suggesting that a non-muscle myosin II-dependent mechanism may be responsible for ensuring proper seam cell asymmetric divisions. I will focus on the role of nmy-2 in this process, mainly by high-resolution microscopy and video lineage analyses of cell divisions in both RNAi-treated worms and mutant worms. Our early evidencesuggests that nmy-2 plays an important role in regulating seam cell asymmetric divisions.
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Grant Details
| Amount Awarded | 156774 |
| Applicant Surname | Ding |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2011-08-31T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 097305/Z/11/Z |
| Lead Applicant | Miss Siyu Ding |
| Partnership Value | 156774 |
| Planned Dates: End Date | 2015-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2011-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof Kim Nasmyth |