Role of mitochondrial protein O-GlcNAcylation in neurons. (360G-Wellcome-097459_Z_11_Z)
Modification of proteins with O-linked N-Acetylglucosamine modification (O-GlcNAcylation) is a reversible post-translational modification that is driven by two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAc hexosaminidase (OGA). The former exists in three splicing isoforms. One of those, mOGT, contains a mitochondrial localisation sequence, but the biological role of protein O-GlcNAcylation in mitochondria is not understood. More recently, mitochondrial dysfunction has been implicated in the pathogenesis of neurodegenerative disorders, in particular Parkinson's and Alzheimer's diseases. In my PhD project I aim to elucidate the role of O-GlcNAc in mitochondria, in particular its role in neuronal function and neurodegeneration. This proposed study will probe the links between energy metabolism in mitochondria, metabolic disorders and neuropathologies. Specifically, the main objectives of my PhD project are: 1. Study the function and localisation of the mitochondrial OGT isoform, 2. Determine the mitochondrial O-GlcNAc proteome, 3. Provide mechanistic biology of regulation of of mitochondrial protein function by O-GlcNAc,4. Probe the link between O-GlcNAc and the development of neurodegeneration.
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Grant Details
| Amount Awarded | 146952 |
| Applicant Surname | Trapannone |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2011-08-31T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 097459/Z/11/Z |
| Lead Applicant | Mr Riccardo Trapannone |
| Partnership Value | 146952 |
| Planned Dates: End Date | 2015-08-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2011-09-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |
| Sponsor(s) | Prof Paul Crocker |