Sir Henry Dale Extension: Inferring the selection history of world-wide populations in relation to phenotypes (360G-Wellcome-098386_A_12_Z)

£519,660

I will construct efficient statistical algorithms to identify selection effects that have several advantages over current approaches, in particular: 1) increased power from exploiting correlations (i.e. linkage disequilibrium) among nearby genetic variants 2) no requirement for classification of individuals into discrete populations that may not have clear ancestral meaning 3) robustness to variant ascertainment bias 4) increased power to detect selection from standing variation 5) ability to test selection in single individuals (e.g. single samples from ancient human remains, or aDNA) These new approaches will automatically identify genetic regions subjected to selection and the individuals affected when jointly analysing data from world-wide groups. Through application to novel genome-wide data obtained through the PI's Sir-Henry-Dale-Fellowship, including > 3700 African individuals from > 100 ethnicities spanning 15 countries, I will identify selection events both unique to and shared amongst geographic regions, pointing to shared past environmental pressures. Using collaborators' world-leading aDNA collections, I will furthermore unearth the timing of selection events. I will test for enrichment of selection signals in gene pathways and/or variants previously associated with phenotypes, elucidating how chronic and infectious disease have driven selection. Overall this fellowship will produce a comprehensive picture of selection effects in humans.

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Grant Details

Amount Awarded 519660
Applicant Surname Hellenthal
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2017-05-31T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Sir Henry Dale Fellowship Extension
Internal ID 098386/A/12/Z
Lead Applicant Dr Garrett Hellenthal
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 519660
Planned Dates: End Date 2020-09-01T00:00:00+00:00
Planned Dates: Start Date 2017-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Francois Balloux