Human Developmental Biology Resource (HDBR): an embryonic and fetal tissue bank for the new genetics technologies. (360G-Wellcome-099175_B_12_Z)

The Human Developmental Biology Resource (HDBR; www.hdbr.org) is unique, being the only tissue-bank that provides the international scientific community with access to: -High-quality materials from human embryonic and early fetal stages, including tissues for cell culture, RNAs from sub-organ specific regions and slides for spatial gene expression studies; -An in-house gene expression service (IHGES) that undertakes studies for registered researchers; -A un ique web-based database for dissemination of human gene expression data spatially mapped to 3D models. To develop HDBR activities, and extend them to meet new challenges and opportunities, our key objectives are: -increase sample collection with a focus on intact specimens; -expand the range of IHGES studies, to include studies of non- coding RNAs and alternative spliced products, and to develop techniques to maximize expression information obtained from rare human tissues; -expand the range of materials provided, e.g. RNA, DNA and protein, from specific tissues to support sequencing, transcriptomics and proteomics projects; -interact strategically with large-scale initiatives focusing on human development and disease. By also improving our engagement with current and potential users, we will adapt the HDBR to meet the needs of functional gene characterisation, for the new genetics technologies.