The role of c-Jun in controlling the repair-supportive phenotype of Schwann cells in injured nerves. (360G-Wellcome-099748_Z_12_A)
Work in the Jessen and Mirsky laboratory, using a mouse in which the transcription factor c-Jun has been inactivated in Schwann cells only (c-Jun-cKO mouse), shows that the Schwann cell response to nerve injury depends on activation of the transcription factor c-Jun in Schwann cells, and that this protein specifies the phenotype of the Bunger repair cell, a cell essential for nerve regeneration. Consequently, nerve repair is severely compromised in c-JuncKO mice. This project will address the following issues: 1) Establish an in vitro model of the regeneration deficit in c-Jun-cKO mice, using adult DRG neurons and Scwann cells from injured nerves. 2) Use this model to analyse Schwann cell factors that control axon growth and neuronal survival. 3) Test whether axonalregeneration and neuronal survival can be improved by enhancing Schwann cell c-Jun expression. 4) Determine whether the diminishing ability of distal nerve tosupport repair with time after injury ( the deterioration of the distal stump ) is due to instability of the Bungner repairsupportive phenotype, and its gradual attenuation. 5) Test whether the repair-supportive Schwann cell phenotype
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Grant Details
Amount Awarded | 40094 |
Applicant Surname | Wagstaff |
Approval Committee | PhD Studentships |
Award Date | 2014-01-17T00:00:00+00:00 |
Financial Year | 2013/14 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 099748/Z/12/A |
Lead Applicant | Ms Laura Wagstaff |
Partnership Value | 40094 |
Planned Dates: End Date | 2016-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2013-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Claudio Stern |