The epidemiology, genomics and longitudinal immune response of Shigella infections in Vietnamese children. (360G-Wellcome-100087_Z_12_Z)
Shigella sonnei is an emergent diarrhoeal pathogen in industrialising countries. Our data from a global S.sonnei collection suggest that this organism is undergoing clonal expansion in Vietnam, influenced by antimicrobial resistance. A lack of a vaccine and a limited understanding of the distribution, incidence and exposure of S.sonnei hinder our ability to control disease and transmission. This project will investigate the genomics, epidemiology, spatial distribution and immune response of S.so nnei infections in Ho Chi Minh City (HCMC). Over 3 years, > 5,000 children from HCMC hospitalised with dysentery will be enrolled, providing a longitudinal collection of S.sonnei and metadata. Risk factors and age-specific incidence of S.sonnei will be assessed by performing active diarrhoeal surveillance for two years in a geographically defined community cohort of 1,000 children. The population structure of S.sonnei in HCMC will be defined by genome sequencing > 1,000 isolates, providing a compr ehensive understanding of the genetic makeup and the temporal, spatial and phylogenetic relationships of S.sonnei in HCMC. Plasma collected through the hospital and cohort components of this project will be assayed to assess the age-specific seroincidence and the true S.sonnei burden. An antigen array will be developed to assess the natural immunogenicity of novel diagnostics and vaccine candidates.
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Grant Details
| Amount Awarded | 1569817 |
| Applicant Surname | Baker |
| Approval Committee | Sir Henry Dale Fellowship Interview Committee |
| Award Date | 2012-11-13T00:00:00+00:00 |
| Financial Year | 2012/13 |
| Grant Programme: Title | Sir Henry Dale Fellowship |
| Internal ID | 100087/Z/12/Z |
| Lead Applicant | Prof Stephen Baker |
| Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
| Partnership Value | 1569817 |
| Planned Dates: End Date | 2018-09-01T00:00:00+00:00 |
| Planned Dates: Start Date | 2013-07-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof Gordon Dougan |