Integrating metabolic and transcriptional circadian clocks. (360G-Wellcome-100333_Z_12_Z)

£2,282,827

My laboratory investigates the molecular mechanisms that control the 24 hour (circadian) clock. This fundamental process is integral to the function of all cells. Our recent work has highlighted a critical role for a family of proteins called peroxiredoxins in the clockwork, and has shown that redox oscillations in mammalian cells contribute significantly to a cell's rhythmic properties. A Senior Fellowship would allow me to examine how the clockwork functions in 'real-time', using a variety of novel tools that we are developing to do this. We will also perturb redox pathways (that normally get rid of harmful oxidants produced because of respiration) and investigate the effect of this on the clockwork using these tools. A final goal will be to integrate redox oscillations with existing components of the clockwork, which rely on the process of gene transcription to work. The goal is therefore to fully characterise the mechanism of how a cell keeps time, particularly with respect to redox metabolism, which is a new and exciting area of study within the field.

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Grant Details

Amount Awarded 2282827
Applicant Surname Reddy
Approval Committee Science Interview Panel
Award Date 2012-11-26T00:00:00+00:00
Financial Year 2012/13
Grant Programme: Title Senior Research Fellowship Clinical
Internal ID 100333/Z/12/Z
Lead Applicant Dr Akhilesh Reddy
Partnership Value 2282827
Planned Dates: End Date 2018-04-23T00:00:00+00:00
Planned Dates: Start Date 2013-08-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Sir Stephen O'Rahilly