Role of grid cell replay in consolidation and navigation (360G-Wellcome-101208_Z_13_A)

£143,293

I aim to build a neural level understanding of how information about the environment is stored, updated, and retrieved from memory. To this end I will study spatial memory and its representation in the rodent hippocampal formation. The results from experimental work including multi-site single unit recordings, pharmacological and optogenetic interventions, along with behavioural manipulations, will be combined with state of the art computational modelling. In turn computational work will suggest and refine further experimental manipulations. This joined-up approach is necessary to close the existing gap between our current neural-level understanding of the brain and cognitive functions. My key goals are to understand: 1) How entorhinal and hippocampal spatial representations are modulated by the level of certainty an animal has about the spatial configuration of its environment. 2) The role of cholinergic modulation in signalling environmental novelty, and more generally spatial u ncertainty. In particular, the effect of cholinergic modulation on theta-frequency rhythmicity and the scale of spatial representations. 3) How changes in the scale of the entorhinal spatial representation may contribute to, and even trigger, memory formation.

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Grant Details

Amount Awarded 143293
Applicant Surname Barry
Approval Committee Science Enhancement Committee
Award Date 2016-02-11T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Enhancement
Internal ID 101208/Z/13/A
Lead Applicant Prof Caswell Barry
Partnership Value 143293
Planned Dates: End Date 2018-11-30T00:00:00+00:00
Planned Dates: Start Date 2016-04-13T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London