A neurocomputational investigation of Pavlovian-instrumental interactions in avoidance. (360G-Wellcome-101521_Z_13_Z)
This proposal has three aims. Firstly, I will characterise the neural computations underlying model-based and model-free avoidance using fMRI in healthy subjects. To do so, I will adapt an existing appetitive paradigm to test if the existing framework can capture human avoidance behaviour. I will seek convergent evidence by comparing a standard version to a version designed to shift individuals towards model-free behaviour, e.g. using outcome volatility. Secondly, I will delineate the nature of the interplay between individual differences in Pavlovian fear conditioning and model-based vs. model-free avoidance by using interleaved Pavlovian conditioning trials. I will then use experimental manipulations to move our understanding of this interaction beyond correlation. I will test if increasing the strength of conditioned Pavlovian fear causes subjects to rely more heavily on model-free avoidance and if biasing individuals towards model-free learning reciprocally increases the strength o f Pavlovian conditioned fear and resistance to extinction. Finally, I will use the models developed at NYU to test causal predictions regarding the role of Pavlovian-instrumental interactions in patients with generalised anxiety disorder and obsessive-compulsive disorder diagnoses. In doing so, I hope to formalise dimensions with well-characterised neurocomputational bases that may explain the familiality and co-morbidity across anxiety disorder diagnoses.
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Grant Details
Amount Awarded | 250000 |
Applicant Surname | Gillan |
Approval Committee | Basic Science Interview Committee |
Award Date | 2013-06-05T00:00:00+00:00 |
Financial Year | 2012/13 |
Grant Programme: Title | Sir Henry Wellcome Postdoctoral Fellowship |
Internal ID | 101521/Z/13/Z |
Lead Applicant | Dr Claire Gillan |
Partnership Value | 250000 |
Planned Dates: End Date | 2017-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2013-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Trevor Robbins |