A putative lipase as a novel toxin/effector in the Pseudomonas aeruginosa typeVI secretion system (360G-Wellcome-102416_Z_13_Z)

£160,280

The bacterial type VI secretion system (T6SS) is a macromolecular complex embedded in the cell envelope of most pathogenic Gram-negative bacteria. This secretion system is a major pathogenicity determinant and is required for Pseudomonas aeruginosa to establish chronic infections in cystic fibrosis patients. The T6SS is evolutionarily, structurally and mechanistically related to the bacteriophage tail, puncturing target cell membranes to deliver its cargo [1].The T6SS secretes toxins into both eukaryotic and prokaryotic cells in order to subvert host responses and to aid competition with other microorganisms. A limited number of T6SS effector proteins have been identified, with the majority displaying antimicrobial activities. The secretion system has no inherent mechanism of self-discrimination, therefore sister cells are only protected through the expression of immunity proteins cognate to the antibacterial effectors. Cognate antitoxins are unnecessary for antieukaryoticeffectors. The proposed research aims to characterise a putative T6SS effector from P. aeruginosa and to study its contribution to pathogenesis. Genetic and biochemical approaches along with cellular biology methods will further our understanding of the arsenal of toxins that this important bacterial pathogen has at its disposal.

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Grant Details

Amount Awarded 160280
Applicant Surname Wood
Approval Committee PhD Studentships
Award Date 2013-06-24T00:00:00+00:00
Financial Year 2012/13
Grant Programme: Title PhD Studentship (Basic)
Internal ID 102416/Z/13/Z
Lead Applicant Mr Thomas Wood
Partnership Value 160280
Planned Dates: End Date 2017-09-30T00:00:00+00:00
Planned Dates: Start Date 2013-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Murray Selkirk