A putative lipase as a novel toxin/effector in the Pseudomonas aeruginosa typeVI secretion system (360G-Wellcome-102416_Z_13_Z)
The bacterial type VI secretion system (T6SS) is a macromolecular complex embedded in the cell envelope of most pathogenic Gram-negative bacteria. This secretion system is a major pathogenicity determinant and is required for Pseudomonas aeruginosa to establish chronic infections in cystic fibrosis patients. The T6SS is evolutionarily, structurally and mechanistically related to the bacteriophage tail, puncturing target cell membranes to deliver its cargo [1].The T6SS secretes toxins into both eukaryotic and prokaryotic cells in order to subvert host responses and to aid competition with other microorganisms. A limited number of T6SS effector proteins have been identified, with the majority displaying antimicrobial activities. The secretion system has no inherent mechanism of self-discrimination, therefore sister cells are only protected through the expression of immunity proteins cognate to the antibacterial effectors. Cognate antitoxins are unnecessary for antieukaryoticeffectors. The proposed research aims to characterise a putative T6SS effector from P. aeruginosa and to study its contribution to pathogenesis. Genetic and biochemical approaches along with cellular biology methods will further our understanding of the arsenal of toxins that this important bacterial pathogen has at its disposal.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 160280 |
Applicant Surname | Wood |
Approval Committee | PhD Studentships |
Award Date | 2013-06-24T00:00:00+00:00 |
Financial Year | 2012/13 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 102416/Z/13/Z |
Lead Applicant | Mr Thomas Wood |
Partnership Value | 160280 |
Planned Dates: End Date | 2017-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2013-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Murray Selkirk |