Genomic analysis to seek mechanisms of resistance to amphotericin B in Leishmania parasites responsible for leishmaniasis (360G-Wellcome-102462_Z_13_Z)
This project proposes to investigate the mechanisms underlying resistance to amphotericin B in parasitic protozoa of the genus Leishmania. The leishmaniases afflict millionsof people across the world and the threat of emerging resistance to current drugs could underlie a public health disaster. Parasites will be selected for resistance in the laboratory and other strains acquired from laboratories where selection has already been undertaken. Field derived isolates will also be acquired. A combination of metabolomic profiling and genome sequencing willidentify candidate genes responsible for resistance and these will be confirmed using genetic manipulation. Genome data available in public repositories will also be analysed to determine the status of any genes found to be associated with amphotericin B resistance in parasites present within the field.
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Grant Details
| Amount Awarded | 149673 |
| Applicant Surname | Pountain |
| Approval Committee | PhD Studentships |
| Award Date | 2013-06-24T00:00:00+00:00 |
| Financial Year | 2012/13 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 102462/Z/13/Z |
| Lead Applicant | Mr Andrew Pountain |
| Partnership Value | 149673 |
| Planned Dates: End Date | 2017-12-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2013-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |
| Sponsor(s) | Prof Darren Monckton |