Macromolecular mechanisms of genome duplication and stability. (360G-Wellcome-104641_Z_14_Z)

£1,867,986

The normal progression of cellular life requires that, each time a cell divides, its genome is duplicated in a complete and faithful manner. Genetic inheritance relies on the biochemical process of DNA replication, which is responsible for the accurate duplication of our genome and the repair of any lesion that might block DNA synthesis or alter the encoded information. In our research, we seek to establish a molecular basis for the orderly duplication of our genome. The extremely stringent requ irements of the duplication process make the study of its molecular mechanisms particularly fascinating. Their analysis is also very timely, as the identity of most of the protein factors involved in genomic duplication are now known, but the biochemical and structural basis of their action is still poorly understood. In addition to its fundamental biological importance, elucidating the molecular basis of DNA replication has great medical relevance, as the genomic instability caused by defective replication is a major predisposing cause of cancer and degenerative pathologies.

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Grant Details

Amount Awarded 1867986
Applicant Surname Pellegrini
Approval Committee Science Interview Panel
Award Date 2014-07-08T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title Investigator Award in Science
Internal ID 104641/Z/14/Z
Lead Applicant Prof Luca Pellegrini
Partnership Value 1867986
Planned Dates: End Date 2020-09-30T00:00:00+00:00
Planned Dates: Start Date 2014-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England