FunVar: Impacts of Genetic Variations on Protein Functions and Functional Pathways. (360G-Wellcome-104960_Z_14_Z)
We will maintain and extend our integrated resources by developing new computational platforms. FunVar will analyse the impacts of genetic variants on the structures/functions of proteins and the networks in which they participate. DISASTR will exploit FunVar to provide web-based reports of impacts for all known, human, disease-associated variants. This will require development and further integration of our resources CATH-Gene3D (Orengo group), a unique, internationally renowned domain stru cture classification, with the functional resources of the Thornton group. CATH-Gene3D classifies ~30 million protein sequences into evolutionary superfamilies and provides information on functions (eg GO). It also describes biological roles by reporting protein interactions/networks. Functional resources in the Thornton group provide complementary data eg protein-ligand interactions (PDBsum) and catalytic residues (CSA). We will provide a unique perspective by focusing on domain structu re and accurately considering the functional role of the domain in its biological context eg complexes/networks. Our resources are unique in classifying domains into functional families. DISASTR will be a new and unique catalogue reporting structural/functional impacts for publicly available genetic variations linked to classified diseases. We will also establish a FunVar webserver for clinicians/biomedical researchers to learn the impacts of novel variants.
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Grant Details
Amount Awarded | 536722 |
Applicant Surname | Orengo |
Approval Committee | Multi-User Equipment Committee (inactive) |
Award Date | 2014-06-25T00:00:00+00:00 |
Financial Year | 2013/14 |
Grant Programme: Title | Biomedical Resources Grant |
Internal ID | 104960/Z/14/Z |
Lead Applicant | Prof Christine Orengo |
Other Applicant(s) | Dr Roman Laskowski, Prof Janet Thornton |
Partnership Value | 536722 |
Planned Dates: End Date | 2021-06-30T00:00:00+00:00 |
Planned Dates: Start Date | 2014-11-24T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |