The role of the blood nerve barrier in peripheral neuropathies. (360G-Wellcome-105205_Z_14_A)

£34,680

The nervous system in maintained in a protective environment by a specialised vasculature. In contrast to the Blood Brain Barrier (BBB), the Blood Nerve Barrier (BNB) is poorly characterised despite having an important role in protecting peripheral nerves and its disruption being associated with neuropathies associated with pathologies such as diabetes and cancer. We have initiated a characterisation of the BNB in the sciatic nerve and have found that it is distinct from the BBB both in its permeability and cellular make-up. Moreover, we have developed a unique transgenic mouse in which ERK signalling in Schwann cells (SCs) in the nerve can reversibly open the barrier, which mimics the normal injury response. This provides a powerful model system for studying in a temporal manner how the BNB can be broken down and reformed. The aims of this proposal are threefold. 1. To characterise the nature of the BNB throughout the PNS and correlate differences with structural changes 2. To determine the role of SC-secreted Semaphorin 3A in the regulation of the BNB. 3. To analyse the expression and role of BBB transporters in the BNB.

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Grant Details

Amount Awarded 34680
Applicant Surname Malong
Approval Committee Internal Decision Panel for C&S
Award Date 2016-09-30T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title PhD Studentship (Basic)
Internal ID 105205/Z/14/A
Lead Applicant Miss Liza Malong
Partnership Value 34680
Planned Dates: End Date 2018-09-21T00:00:00+00:00
Planned Dates: Start Date 2014-09-22T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof David Attwell